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A CO-oximeter can be used to determine carboxyhemoglobin levels. If a relatively excessive stage of carbon monoxide is detected, the machine sounds an alarm, giving individuals the possibility to evacuate and ventilate the building. The biological threshold for carboxyhemoglobin tolerance is usually accepted to be 15% COHb, which means toxicity is constantly noticed at ranges in excess of this focus. As folks may proceed to experience significant signs of CO poisoning lengthy after their blood carboxyhemoglobin focus has returned to regular, presenting to examination with a normal carboxyhemoglobin level (which may occur in late states of poisoning) does not rule out poisoning.

Furthermore, the mechanism for formation of carbaminohemoglobin generates extra 'acidic' hydrogen ions that may further stabilize the protonated/ionized deoxygenated hemoglobin. The mechanism that is thought to have a significant influence on delayed effects involves formed blood cells and chemical mediators, which trigger brain lipid peroxidation (degradation of unsaturated fatty acids).